ALLOSTERIC MODULATORS OF METABOLIC GLUTAMATE RECEPTORS Russian patent published in 2009 - IPC C07D211/16 C07D401/04 C07D413/04 C07D413/14 C07D417/14 A61K31/4523 A61P25/18 A61P25/28 

FIELD: chemistry; medicine.

SUBSTANCE: compounds of claimed invention possess properties of positive allosteric modulator mGluR5. In general formula I , W represents 6-member heterocycloalkyl ring with 1-2 heteroatoms, selected from N, O; R₁ and R₂ independently represent hydrogen, C₁-C₆-alkyl; P and Q each independently is selected from: , R₃, R₄, R₅, R₆ and R₇ independently represent hydrogen; halogen; -CN; nitro; C₁-C₆-alkyl; C₃-C₆-cycloalkyl; halogen-C₁-C₆-alkyl; 5-6-member heteroaryl with 1-2 atoms N as heteroatoms; 6-member heterocycle with 2 heteroatoms representing N, O; phenyl, optionally substituted with halogen; naphtyl; -OR₈; where optionally two substituents together with located between them atoms form 9-10-member bicyclic aryl or heteroaryl ring with 1-2 heteroatoms, selected from N, S; R₈ represents hydrogen, C₁-C₆-alkyl; D, E, F, G and H independently represent -C(R₃)=, -O-, -N=, -N(R₃)- or -S-; A represents ethinyl, -C(=O)NR₈- or group of formula . B represents -C(=O)-C₀-C₂-alkyl-, -C(=O)-C₂-C₆-alkenyl-. Invention also relates to pharmaceutical composition based on invention compounds.

EFFECT: novel compounds possess useful biological proprties.

20 cl, 3 dwg, 75 ex