ARYLSULPHONAMIDE CCR3 ANTAGONISTS Russian patent published in 2015 - IPC C07D295/26 A61K31/495 A61P11/06 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula , where: R¹, R², R³, R⁴, R⁵ and R⁶, each independently, denote hydrogen, halogen, cyano, nitro or C_1-6alkyl; X denotes O or S; R^Ya denotes -C(O)R^1a, -C(O)OR^1a, -C(O)NR^1bR^1c, -C(S)NR^1bR^1c, -C(NNO₂)NR^1bR^1c, -S(O)₂R^1a or -S(O)₂NR^1bR^1c; under the condition that R^Ya is not -C(O)O-tert-butyl; and each R^1a, R^1b and R^1c independently denotes hydrogen, C_1-6alkyl, C_2-6alkenyl, C_3-7cycloalkyl, C_6-14aryl, 5-10-member heteroaryl containing one, two or three heteroatoms selected from O, N or S, or morpholinyl; or each pair of R^1b and R^1c, together with the N atom to which they are bonded, independently forms morpholinyl; under the condition that the compound is not 4-(2-(3,5-dimethylphenoxy)-5-nitrophenylsulphonyl)piperazine-1-carbaldehyde; wherein each alkyl, alkenyl, aryl and 5-10-member heteroaryl, containing one, two or three heteroatoms selected from O, N or S, is optionally substituted with one or more groups, each independently selected from (a) cyano, halogen and nitro; (b) C_1-6alkyl, C_6-14aryl, furanyl and morpholinyl, each optionally substituted with one or more substitutes Q; (c) -C(O)R^a, -C(O)OR^a, -OR^a and -SR^a, wherein each Q is independently selected from a group consisting of (a) cyano, halogen and nitro; (b) C_1-6alkyl and C_2-6alkenyl; and (c) -C(O)R^e, -C(O)OR^e, and -SR^e; where each R^e, R^f and R^g independently denotes (i) hydrogen; (ii) C_1-6alkyl or C_2-6alkenyl, which are suitable for modulating CCR3 activity.

EFFECT: obtaining compounds which are suitable for modulating CCR3 activity.

41 cl, 1 tbl, 4 ex