NOVEL 3-PHENYLPROPIONIC ACID DERIVATIVES FOR TREATING DIABETES Russian patent published in 2009 - IPC C07D263/58 C07D277/82 C07D277/74 C07D413/12 A61K31/423 A61K31/428 A61P3/10 

FIELD: chemistry; medicine.

SUBSTANCE: invention relates to 3-phenylpropionic acid derivatives of formula (I) as ligand of peroxisome proliferator-activated gamma-receptor (PPARγ), to their pharmaceutically acceptable salts, as well as to their application, treatment method and based on them pharmaceutical composition. Compounds can be applied for treatment and prevention of diseases mediated by peroxisome proliferator-activated gamma-receptor (PPARγ), for instance type 2 diabetes, insulin-resistance, metabolic syndrome, complications resulting from or connected with diabetes, cardio-vascular dysfunctions, atherosclerosis, obesity, cognition disturbances and lipid metabolism derangements. In general formula (I): W represents COOH or -COO-C₁ - C₄-alkyl group; Y represents NH; Z represents S or O; X represents O; R₁ - R₈ each independently represents hydrogen atom or halogen atom; A represents mono-, bi- or tri-cyclic 5-13-member heteroaryl with 1 or 2 heteroatoms selected from N, S or O, aryl, selected from phenyl and naphtyl, or -N(C₁-C₄-alkyl)-CO-C₃-C₇-cycloalkyl, where heteroaryl is optionally substituted with 1-3 substituents, independently selected from group, consisting of C₁-C₄-alkyl, CN, phenyl halogen and phenyl, optionally substituted with 1-3 substituents, independently selected from C₁-C₄alkoxy, halogen and ethylenedioxy-group; and n represents integer number from 0 to 3 including; and their pharmaceutically acceptable salts.

EFFECT: increased efficiency of composition and treatment method.

20 cl, 14 dwg, 10 ex