NEW DERIVATIVES OF 3-PHENYLPROPIONIC ACID Russian patent published in 2009 - IPC C07D277/42 C07D417/12 C07D263/38 C07D233/84 A61K31/426 A61K31/427 A61K31/421 A61K31/4164 A61P3/10 

FIELD: chemistry.

SUBSTANCE: compounds of the invention can be used for treating or preventing diseases and conditions, mediated by peroxisome proliferator activated gamma receptor (PPARγ). In formula (I) W represents a COOH group or -COOC-C₁-C₄alkyl; Y represents NH; Z represents S or O; X represents O; R₁-R₆ each independently represents a hydrogen atom or substitute, chosen from a group consisting of: C₁-C₄-alkyl, thienyl or phenyl, where phenyl is optionally substituted with one or more substitutes, independently chosen from a group consisting of C₁-C₄-alkyl, C₁-C₄-alkoxy, a halogen atom; -NO₂ and -CN; A represents C₁-C₄-alkyl, -N(C₁-C₄-alkyl)-CO-C₃-C₇-cycloalkyl, aryl, chosen from a group consisting of phenyl, naphthyl, or heteroaryl, chosen from a group consisting of oxazolyl, isoxazolyl, thienyl, pyridyl, thiazolyl, thiadiazolyl, benzo[b]thienyl, imidazolyl, indolyl and carbazolyl, where aryl and heteroaryl are substituted or not substituted with one or more substitutes, independently chosen from a group consisting of C₁-C₄-alkyl, C₁-C₄-alkoxy, phenyl and a halogen atom; and n is an integer from 0 to 4. The invention also relates to a pharmaceutical composition, containing the invented compound as an active component, use of the compounds to make a medicinal agent, and method of treatment.

EFFECT: obtaining new biologically active compounds.

22 cl, 6 ex