BREAST CANCER OUTCOME PREDICTION METHOD Russian patent published in 2009 - IPC G01N33/68 

FIELD: medicine.

SUBSTANCE: invention refers to medicine area, namely to oncology. Breast cancer (BC) outcome prediction method involves biochemical examination of tumour tissue for activity of aromatase, 2,4-oestrogenhydroxylase and glutathione-S-transferase. If activity of aromatase is less than 20 fmole/mg of protein per hour, activity of 2,4-oestrogenhydroxylases is more than 230 pmole/mg of protein per hour regardless activity of glutathione-B-transferase, high probability of recurrence is predicted. If activity of glutathione-S-transferase is less than 40 mkmol/mg of protein per minute without changes in other indicators, high probability of distant metastases are predicted. If activity of aromatase is more than 20 fmol/mg of protein per hour, activity of 2,4-oestrogenhydroxylases is less than 230 pmol/mg of protein per hour, activity of glutathione-S-transferase is more than 40 mkmol/mg of protein per minute, favourable clinical outcome of the disease in recurrence development and/or remote metastases is predicted.

EFFECT: high-accuracy and informative prediction of disease progressing in the form of tumour recurrences and/or metastases within first 2 years in BC patients after radical surgical treatment.

2 ex, 3 dwg