METHOD FOR DETERMINING THE EFFECTIVENESS OF CHEMOTHERAPY WITH PLATINUM PREPARATIONS IN III-IV STAGE OVARIAN CANCER Russian patent published in 2020 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, and can be used for early detection of efficacy of antitumour treatment of ovarian cancer III-IV stage. Method involves complete or optimal/suboptimal cytoreductive volume following 3 courses of non-adjuvant polychemotherapy with platinum preparations for patients with ovarian cancer III-IV stage. Tissue fragment of the primary malignant tumor, as well as the metatastically involved omentum and peritoneum in volume of 100-120 mg are sampled, tissue 10% homogenate is prepared in a buffered physiological saline of pH 7.4, protein HE-4 level is determined in the samples. If its value is 170.0-186.6 pmol/l in primary malignant tissue, in tissue of metastatic diseased omentum 153.1-175.5 pmol/l and in tissue of metastatically involved peritoneum 128.7-149.7 pmol/l effectiveness of postoperative chemotherapy with platinum preparations used in neoadjuvant mode is predicted. If the value in the primary malignant tissue within range of 1667.6-1976.2 pmol/l, in tissue of metastatically involved greater omentum 1109.6-1307.0 pmol/l and in tissue of metastatically involved peritoneum 1429.2-1693.4 pmol/l absence of efficacy of postoperative chemotherapy with platinum preparations used in neoadjuvant mode is predicted.

EFFECT: use of the invention enables assessing the efficacy of the neoadjuvant polychemotherapy with platinum preparations in ovarian carcinoma by the levels of the tumor markerHe-4 in the tissues of primary and metastatic tumors to predict the effectiveness of subsequent courses of platinum-containing chemotherapy.

1 cl, 4 ex