DERIVATIVE OF CYCLIC AMIDE, OBTAINING SAID DERIVATIVE AND USE Russian patent published in 2009 - IPC C07D211/76 C07D401/04 C07D413/04 C07D403/04 C07D417/04 A61K31/506 A61K31/5377 A61K31/45 A61P7/02 

FIELD: chemistry.

SUBSTANCE: in new compounds with general formula (I): , R¹ stands for a naphthyl group, which can be substituted with a halogen atom, W represents a bond, a equals 0, 1 or 2, X¹ represents C_1-4alkylene, which can be substituted with a hydroxy group, Y¹ represents -C(O)-,A represents a piperazine ring or piperidine ring, X² represents a bond, Y² represents -C(O)-, -S(O)₂- or -C(=NR⁷)- (where R⁷ represents a hydrogen atom), X³ represents C_1-4alkylene, which can be substituted with a hydroxyl group, oxo group or C_1-6alkyl group; or C_2-4alkylene, which can be substituted with a C_1-6alkyl group, where two alkyl groups can be bonded to each other forming, together with carbon atoms to which they are bonded, an aryl ring when X³ represents C_2-4alkylene, substituted with two alkyl groups, Z³ represents -N(R⁴)- or a bond (where R⁴ represents a hydrogen atom, C_1-6alkyl group, which can be substituted with a hydroxy group or methoxy group, or acyl group), represents a single or double bond, where if represents a single bond, then Z¹ represents -C(R²)(R^2')-, -N(R²)- or -O- and Z² represents C(R³)(R^3')-, -N(R³)-, -O- or a bond (under the condition that, when Z² represents -O-, then Z is different from -O-), and when represents a double bond, then Z¹ represents -C(R³)= or a nitrogen atom and Z² represents =C(R³)- or a nitrogen atom, each of R², R^2', R³ and R^3' represents a hydrogen atom or C_1-6alkylene. The invention also relates to salts of the given new compounds. The invention also relates to compounds, chosen from the group, to pharmaceutical compositions, to use of compounds in sub-paragraph 1 or 2, to prevention or treatment methods, as well as to the method of obtaining compounds in paragraph 1.

EFFECT: obtaining new biologically active compounds, which inhibit activated factor X of blood clotting and have anticoagulation activity and antithrombotic activity.

33 cl, 46 ex, 1 tbl