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(19)

(11)

2 361 869

(13)

(51)

IPC

C07D295/04(2006-01-01)

C07D401/04(2006-01-01)

C07D403/04(2006-01-01)

A61K31/496(2006-01-01)

A61P3/10(2006-01-01)

(21) (22)

Application

2004126680/04, 2003-02-05

(24)

Start date

2003-02-05

(22)

Actual filing date

2003-02-05

(45)

Published

2009-07-20

(72)

Inventor

Khol'Veg Rol'FDerval'D Florensio ZaragozaStefensen KhenrikPettersson IngridPeshke Bernd

(73)

Holder

Khaj Pojnt Farmas'Jutikalz, Ehlehlsi

NEW ARYL - AND HETEROARYLPIPERAZINES Russian patent published in 2009 - IPC C07D295/04 C07D401/04 C07D403/04 A61K31/496 A61P3/10

Abstract RU 2361869 C2

FIELD: chemistry.

SUBSTANCE: invention relates to aryl or heteroarylpiperazines with general formula II , where R² is hydrogen or C_1-4-alkyl (i) R¹ is branched C_4-6-alkyl, branched C_4-6-alkenyl or branched C_4-6-alkynyl, under the condition that R¹ is not isobutyl, - C_3-5-cycloalkyl, C_3-7-cycloalkenyl, C_3-6-cycloalkyl-C_1-3-alkyl or C_3-6-cycloalkenyl-C_1-3-alkyl, -R¹ and R² together form a C_3-6-alkylene bridge, and A is or or (ii) R¹ - is ethyl, n-propyl or isopropyl, - R¹ and R² together form a C_3-6-alkylene bridge, and A is or . Described also is a pharmaceutical composition based on formula II compounds, use of formula II compounds and method of treatment.

EFFECT: compounds exhibit high and selective bonding affinity to histamine H3 receptor and can be used for treating diseases and disorders, related to histamine H3 receptor.

49 cl, 149 ex

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RU 2 361 869 C2

Authors

Khol'Veg Rol'F

Derval'D Florensio Zaragoza

Stefensen Khenrik

Pettersson Ingrid

Peshke Bernd

Dates

2009-07-20—Published

2003-02-05—Filed