POLYCYCLIC COMPOUNDS AND METHODS FOR THEIR USE Russian patent published in 2018 - IPC C07D495/04 C07D495/20 C07D333/58 C07D277/60 A61K31/381 A61K31/428 A61P25/18 A61P25/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound having the formula

or a pharmaceutically acceptable salt or stereoisomer thereof. In the formula (IVa): (i) R¹ and R³ together with the atoms to which they are attached form an optionally substituted 3-20 membered heterocyclyl and R⁴ is hydrogen; or (ii) R³ and R⁴ together form a double bond and together with R¹ and the atoms to which they are attached form an optionally substituted 5-20 membered heteroaryl; R² is hydrogen, C_1-6alkyl or absent; R⁵ is hydrogen; R⁶ and R⁷ are hydrogen; m is 0; n is 1; and wherein heterocyclyl or heteroaryl may be substituted by one or more substituents selected from C_1-6alkyl. And heterocyclyl is a monocyclic or polycyclic ring system, which contains at least one non-aromatic ring containing one or more heteroatoms, selected from N, and the rest of the ring atoms are carbon atoms, heteroaryl is a monocyclic or polycyclic ring system, which contains at least one aromatic ring containing one or more heteroatoms, independently selected from S and N. A pharmaceutical composition and a method for neurological disorder treatment are also proposed.

EFFECT: compound of the formula is used to treat neurological disorders.

31 cl, 2 tbl