2,5-DISUBSTITUTED ARYLSULPHONAMIDE CCR3 ANTAGONISTS Russian patent published in 2014 - IPC C07D211/96 C07D241/04 C07D243/08 C07D403/04 C07D487/04 C07D295/26 C07C311/29 A61K31/445 A61K31/495 A61K31/5375 A61K31/54 A61K31/551 A61P25/28 A61P11/06 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I, possessing a modulating action with respect to the CC chemokine receptor 3 (CCR3), a based on them pharmaceutical composition, versions of treatment methods and a method of controlling the CCR3 activity. In the general formula I R¹ and R² represent halogen or C_1-6alkyl; R³ represents cyano or nitro; R⁴ represents or ; R⁵ represents oxo; C_1-6alkyl, optionally substituted with halogen atoms; or C(O)OR^1a; X represents O or S; Y represents -O-, -S-, -N(R^1a)-, -C(R^1a)(R^1d)- or -C(R^1a)(NR^1bR^1c)-; m represents an integer number from 0 to 2; n represents 1; p represents an integer number from 0 to 2; r represents 1 or 2; and each R^1a, R^1b, R^1c and R^1d represents (a) hydrogen; (b) C_3-7cycloalkyl; or (c) C_1-6alkyl, optionally substituted with hydroxyl, or each pair R^1b and R^1c together with a N atom, which they are bound to, form imidazoimidazolyl, substituted with oxo, butyl or chlorine, or heterocycle, containing 5 or 6 atoms in a cycle.

EFFECT: improvement of the composition properties.

41 cl, 2 tbl, 7 ex