MEDICINAL FORMULATION POSSESSING ANTI-ANGINAL EFFECT AND METHOD FOR ITS PREPARING Russian patent published in 2006 - IPC A61K31/495 A61K9/36 A61K9/22 A61J3/10 A61P9/10 

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to a medicinal formulation consisting of a core comprising the following components, wt.-%: trimetazidine dihydrochloride, 9.0-32.0; hydroxypropylcellulose, 3.0-10.5; hydroxyethylcellulose, 18.5-67.2; sodium alginate, 0.1-0.6; calcium phosphate dihydrate, 19.0-28.5; magnesium stearate, 0.5-2.0; talc, 0.5-2.0, and envelope comprising the following components, wt.-%: one component chosen from the group including hydroxypropylcellulose, water-soluble methylcellulose or hydroxypropylcellulose, 0.6-2.7; Tween-80, 0.3-1.2; pigment titanium dioxide, 0.1-1.0 and red iron oxide, 0.1-0.8. Method for preparing the medicinal formulation is carried out by wet granulation, tabletting prepared granules and applying the envelope from an aqueous suspension by spraying preferably. Release of trimetazidine dihydrochloride in the body from the new proposed formulation is carried out for 8 h that provides the constant level of the preparation in blood.

EFFECT: improved preparing method, valuable pharmaceutical properties of formulation.

3 cl, 2 tbl, 1 ex