NOVEL PYRAZOLE DERIVATIVES Russian patent published in 2019 - IPC C07D471/04 A61K31/437 A61K31/444 A61K31/497 A61K31/506 A61K31/5377 A61P25/16 A61P25/18 A61P25/28 C07D401/04 C07D403/04 C07D417/04 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. In formula (I), p is an integer from 0 to 3; q is an integer from 0 to 1; Z is N or CR⁵; every R¹ independently represents a fluorine atom, a chlorine atom, a bromine atom, a cyano group, a methyl group, an ethyl group, an isopropyl group, a tert-butyl group, a vinyl group, a hydroxyethyl group, a cyclopropyl group, a difluoromethyl group, a trifluoromethyl group, a methoxy group, an ethoxyethyl group or an acetyl group, R² represents a methyl group; every R³ independently represents a fluorine atom or a chlorine atom; R⁴ represents a phenyl group, a pyridyl group, a pyrolidinyl group or a morpholinyl group, moreover, the phenyl group, pyridyl group, pyrolidinyl group and morpholinyl group, which represent R⁴, are optionally substituted with one to two groups selected from a fluorine atom, a methyl group, a trifluoromethyl group, a methoxy group, and a methoxymethyl group; R⁵ represents a hydrogen atom, a fluorine atom; ring A, which is represented by partial structural formula (II), is a 5–6 membered monocyclic heteroaryl group, which has a structure in that the pyrazole ring is directly connected in position 4 to position α in relation to the nitrogen atom of a 5–6-membered monocyclic heteroaryl group, and selected from the group of heteroaryl specified in the claims; R⁶ represents a methyl group; and condensed ring B that is represented by partial structural formula (III). Also the invention relates to a compound represented by formula (Ib), a compound represented by formula (Id), to individual compounds, to pharmaceutical compositions, to an agent for preventing and / or treating at least one disease or condition associated with PDE10, to a PDE10 inhibitor, to a treatment method, to a compound represented by formula (I ').

EFFECT: technical result: new compounds with inhibitory action against phosphodiesterase 10 (PDE10) are obtained.

34 cl, 59 tbl, 181 ex