HYSTONE DESACETYLASE INHIBITORS FROM NOVEL BENZAMIDE DERIVATIVES WITH STRONG DIFFERENTIAL ANTI-PROLOFERATIVE ACTIVITY Russian patent published in 2009 - IPC C07D213/56 C07C233/51 C07C237/40 A61K31/4406 A61K31/165 A61P17/06 A61P35/00 

Abstract RU 2364589 C2

FIELD: chemistry.

SUBSTANCE: claimed invention relates to formula I compounds and their pharmaceutically acceptable salts. Compounds of claimed invention can be applied as medication for treating disorders induced by cell proliferation or mediated by nucleus receptors. In general formula , A represents phenyl or unsaturated monocyclic 6-member group, containing nitrogen atom as heteroatom; B represents phenyl group; Z represents bond; Y represents group -CO-NH-CH2-; R1, R2, R3 independently represent hydrogen; R4 represents aminogroup; and one of X1, X2 , X3 or X4 represents halogen atom, while other ones of X1, X2, X3 or X4 independently represent hydrogen atom.

EFFECT: invention also relates to method of obtaining, pharmaceutical compositions, to application of invention compounds, as well as to formula IV compound.

22 cl, 1 dwg, 2 tbl, 7 ex

Similar patents RU2364589C2

Title Year Author Number
NAPHTHALENE CARBOXAMIDE DERIVATIVES AS PROTEIN KINASE AND HISTONE DEACETYLASE INHIBITORS, METHODS FOR PREPARING AND USING THEM 2010
  • Lu Sjan'Pin
  • Li Chzhibin'
  • Shan' Sun
  • Juj Tszin'Di
  • Nin Chzhitsjan
RU2497809C2
BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETILASE INHIBITORS 2006
  • Ehndr'Jus Dejvid Majkl
  • Stouks Ehlejn Sofi Ehlizabet
  • Terner Ehndr'Ju
  • Uoring Majkl Dzhejms
RU2448965C2
MACROCYCLIC COMPOUNDS, APPLIED AS HISTONE DEACETYLASE INHIBITORS 2011
  • Lju Sjuehdun
  • Fillips Ehndrju Dzh.
  • Ungermannova Dana
  • Nasveschuk Kristofer G.
  • Chzhan Gan
RU2565076C2
HDAC INHIBITORS 2014
  • Zhak Vensan
  • Rushe Dzhejms R.
RU2665554C2
4-(3-((2-ADAMANTYL)AMINO)-3-OXOPROP-1-EN-1-YL)-N-HYDROXYBENZAMIDE - A NEW DRUG FOR THE TREATMENT OF ALZHEIMER'S DISEASE 2022
  • Neganova Margarita Evgenevna
  • Aleksandrova Yuliya Romanovna
  • Munkuev Aldar Ayurovich
  • Suslov Evgenij Vladimirovich
  • Volcho Konstantin Petrovich
  • Salakhutdinov Nariman Faridovich
RU2783995C1
HETEROCYCLIC ALKYL DERIVATIVE COMPOUNDS AS THE HISTONE DEACETYLASE SELECTIVE INHIBITORS AND CONTAINING THEM PHARMACEUTICAL COMPOSITIONS 2016
  • Lee, Changsik
  • Lee, Jaekwang
  • Song, Hyeseung
  • Bae, Daekwon
  • Ha, Nina
  • Kim, Il Hyang
RU2683022C1
METHODS OF REDUCING CACHEXIA ASSOCIATED WITH CANCER 2014
  • Chen Chin-Shikh
  • Bekaii-Saab Tanios
  • Gattridzh Denis
  • Markuchchi Gvido
  • Kalp Samyuel
  • Tsen Yuj-Chou
RU2692785C1
HISTONE DEACETYLASE INHIBITORS 2008
  • Radzhagopal Sridkharan
  • Kachkhadia Virendra
  • Ponpandian Tkhanasekaran
  • Kiri Abdul Rakhim
  • Anandkhan Karnambaram
  • Radzhagopal Sriram
  • Pravin Radzhendran
  • Dajvasigamani Prabkhu
RU2453536C2
HYDROXAMIC ACIDS, DERIVATIVES OF 4-AMINOQUINAZOLINE-7-CARBOXYLIC ACID AS INHIBITORS OF HISTONE DEACETYLASE, AND METHOD FOR SYNTHESIS THEREOF 2021
  • Osipov Vasilij Nikolaevich
  • Khachatryan Derenik Sarkisovich
  • Kolotaev Anton Vladimirovich
  • Gromyko Aleksandr Viktorovich
  • Khochenkov Dmitrij Aleksandrovich
  • Gusev Dmitrij Vasilevich
  • Borisova Larisa Mikhajlovna
RU2779981C1
N1-(4-(5-(CYCLOPROPYLMETHYL)-1-METHYL-1H-PYRAZOLE-4-YL)PYRIDINE-2-YL)CYCLOHEXANE-1,4-DIAMINE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF CK1 AND/OR IRAK1 FOR THE TREATMENT OF CANCER 2018
  • Li, Dansu
  • Snir-Alkalaj, Irit
  • Vakka, Jozef
  • Ben Neriakh, Jinon
  • Venkatak-Ialam, Avantika
RU2761457C2

RU 2 364 589 C2

Authors

Lu Sjan'-Pin

Li Chzhibin'

Se Ajkhua

Li Bojuj

Nin Chzhitsjan

Shan' Sun

Dehn To

Khu Vehjmin

Dates

2009-08-20Published

2004-02-09Filed