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2 448 965

(13)

(51)

IPC

C07D401/06(2006-01-01)

A61K31/454(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2008119411/04, 2006-10-17

(24)

Start date

2006-10-17

(22)

Actual filing date

2006-10-17

(45)

Published

2012-04-27

(72)

Inventor

Ehndr'Jus Dejvid MajklStouks Ehlejn Sofi EhlizabetTerner Ehndr'JuUoring Majkl Dzhejms

(73)

Holder

Astrazeneka Ab

BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETILASE INHIBITORS Russian patent published in 2012 - IPC C07D401/06 A61K31/454 A61P35/00

Abstract RU 2448965 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to benzamide compounds of formula (IA) where R², R³ and R⁵ each is independently selected from hydrogen or metal or their pharmaceutically acceptable salts. Compounds of formula (IA) are inhibitors of histone deacetilase.

EFFECT: elaboration of method of obtaining formula (IA) compounds, pharmaceutical composition, which contains them, and their application for preparation of medication for application as anti-proliferative means for prevention or treatment of tumours or other proliferative conditions, which are sensitive to inhibition of histone deacetilase.

17 cl, 2 tbl, 11 ex

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RU 2 448 965 C2

Authors

Ehndr'Jus Dejvid Majkl

Stouks Ehlejn Sofi Ehlizabet

Terner Ehndr'Ju

Uoring Majkl Dzhejms

Dates

2012-04-27—Published

2006-10-17—Filed