HETEROCYCLIC ALKYL DERIVATIVE COMPOUNDS AS THE HISTONE DEACETYLASE SELECTIVE INHIBITORS AND CONTAINING THEM PHARMACEUTICAL COMPOSITIONS Russian patent published in 2019 - IPC C07D211/18 C07D211/22 C07D211/58 C07D211/62 C07D211/96 C07D213/36 C07D241/04 C07D295/205 C07D471/10 A61K31/435 A61K31/4965 

FIELD: chemistry.

SUBSTANCE: invention relates to the compound represented by formula I, its optical isomer, or its pharmaceutically acceptable salt. In formula I, X represents a heterocyclic alkyl selected from the group consisting of

and ,

where each Z and W are independently CH or N, at that, at least one of Z and W is N, each a, b, c and d are independently 1, 2 or 3, each R₃, R₄, R₅ and R₆ independently represent -H or -C₁-C₄-alkyl; Y is C or N; each A and B independently represent -C₁-C₄ alkyl, -C₆-C₁₀ aryl, -C₃-C₁₂ N-containing heteroaryl, where -C₆-C₁₀ aryl can be independently unsubstituted or one or more hydrogen atoms therein can be substituted with -CF₃ or halogen; Q is C = O or SO₂; R₁ represents -H or -C₁-C₄ alkyl; R₂ represents -H, -OH, halogen or absent; n is equal to 1, 2, 3 or 4. Invention also relates to the pharmaceutical composition, to the histone deacetylase mediated disease treatment method, and to the said compound use for the histone deacetylase mediated disease treatment medicine manufacturing.

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EFFECT: disclosed is the compound with inhibitory activity against histone deacetylase (HDAC).

8 cl, 1 dwg, 4 tbl, 27 ex