FIELD: chemistry.
SUBSTANCE: invention relates to novel class of photosensibilisers for photodynamic therapy - N,N-difluorboryl complexes of N-(3-aryl-2H-isoindol-1-yl)-N-(3-aryl-1H-isoindol-1-ylidene)amines of general formula: , where R=H,C1-C4-alkyl, OC1-C4-alkyl, Ph, Br, as well as to method of obtaining them lying in processing of respective ligand with boron trifluoride etherate in presence of secondary or tertiary amine in boiling benzole.
EFFECT: described photosensibilisers possess high photoinduced activity and are promising for practical application in photodynamic therapy method.
2 cl, 7 ex, 2 tbl
Title | Year | Author | Number |
---|---|---|---|
METHOD OF PRODUCING N, N-BIS (5-AMINO-3-ALKYL-1,3,4-THIADIAZOLE-2-YLIDENE) -2H-ISOINDOLE-1,3-DIAMINES | 2015 |
|
RU2612259C1 |
ALKYLTHIOSUBSTITUTED PHTALOCYANIDES, THEIR MEDICINAL FORMS AND METHOD OF PHOTODYNAMIC THERAPY | 2007 |
|
RU2340615C1 |
N, N-BIS(5-AMINO-3-PENTYL-1,3,4-THIADIAZOL-2-YLIDENE)-2H-ISOINDOLE-1,3-DIAMINE | 2008 |
|
RU2373205C1 |
METHOD OF PRODUCING NON-METAL TETRAAZACHLORINS | 2012 |
|
RU2479586C1 |
PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY | 1998 |
|
RU2164136C2 |
SULFOSUBSTITUTED PHTHALOCYANINES AS PHOTOSENSITIZING AGENTS FOR PHOTODYNAMIC THERAPY | 1999 |
|
RU2183635C2 |
TETRAAZACHLORINES AS PHOTOSENSIBILIZATORS FOR PHOTODYNAMIC THERAPY | 2004 |
|
RU2278119C1 |
PHOTOSENSIBILIZING AGENT, LIPOSOMAL FORMULATION OF PHOTOSENSIBILIZING AGENT AND METHOD FOR CARRYING OUT PHOTODYNAMIC THERAPY | 2004 |
|
RU2257898C1 |
DERIVATIVES OF 13(1)-N-{2-[N-(CLOSO-MONOCARBADODECABORAN-1-YL)- METHYL]AMINOETHYL}AMIDE-15(2),17(3)-DIMETHYL ETHER OF CHLORINE e, MANIFESTING PROPERTIES OF PHOTOSENSITISER | 2009 |
|
RU2406726C1 |
PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY OF PROSTATE CANCER AND METHOD FR MANUFACTURING THEREOF | 2018 |
|
RU2670087C1 |
Authors
Dates
2009-08-20—Published
2008-01-14—Filed