QUINAZOLINE COMPOUNDS Russian patent published in 2009 - IPC C07D403/12 C07D471/04 C07D239/72 C07D239/86 C07D239/88 C07D401/14 C07D491/04 A61K31/517 A61P35/00 

FIELD: chemistry.

SUBSTANCE: claimed invention relates to compounds of formula IId and their pharmacologically acceptable salts. In formula IId M represents -CH- or -N-; R^2c bonded with carbon atom of 5-member ring and is selected from hydrogen and methyl; R^2d is bonded with carbon atom from 6-member ring and selected from hydrogen and fluorine; one of R^2a and R^2b represents methoxy, and other is Q¹X¹, where X¹ represents -O-, and values of other radicals are given in formula IId, to pharmaceutical composition, inhibiting antiogenesis and/or reducing vessel permeability, which contains as active component compound of formula IId, to application of invention compounds for preparation of medication and to compounds of 7-benzyloxy-4(4-fluorine-2-methylindol-5-iloxy)-6-methoxyquinazoline and 4-(4-fluorine-2- methylindol -5-yloxy)-7-hydroxy-6-methoxyquinazo-line.

EFFECT: development of effective method of obtaining quinazoline compounds.

12 cl, 54 ex