NEW ARYL AMIDINE DERIVATIVE, ITS SALT AND ANTIFUNGAL PREPARATION CONTAINING SUCH COMPOSITIONS Russian patent published in 2009 - IPC C07D211/22 A61K31/445 A61P31/10 

FIELD: chemistry.

SUBSTANCE: invention is related to new aryl amidine derivatives, which are represented by general formula: , where R¹ represents amidine group, which is not necessarily substituted by one or several groups, which represent acyl group; alkyloxycarbonyl group; aralkyloxycarbonyl group; aryloxycarbonyle group; cycloalkyloxycarbonyl group alkoxyalkyl group; cycloalkylydene group; hydroxyl group, which is not necessarily substituted with acyl group; aloxy and aralkyloxy groups, which are not necessarily substituted by halogen, alkyl group, alkoxy group, alkoxyalkyl group, amides; and R² and R³ are same or different from each other, and every one represents hydrogen or halogen atom; or to its salt. Invention is also related to 4-{3-[4-(3-{4-[amino (imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine, 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine trihydrochloride pentahydrate, 4-{3-[4-(3-{4-[amino (hydroxyimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidoxim or to their salts, and also to antifungal composition.

EFFECT: preparation of new biologically active compounds that possess antifungal activity.

7 cl, 49 ex