BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS Russian patent published in 2009 - IPC C07D211/62 C07D401/12 A61K31/4523 A61K31/4545 A61P11/06 A61P11/08 

FIELD: chemistry.

SUBSTANCE: present invention refers to the new compounds of formula I: whereat : a is 0 or 1; R¹ means halogen; b is 0 or 1; R² means halogen; m is 0 or 1; R⁴ is selected from hydrogen, (1-4C)alkyl and (3-4C)cycloalkyl; s is 0, 1 or 2; Ar¹ is phenylen group or (3-5C)heteroarylen group containing 1 or 2 heteroatom independently selected from oxygen, nitrogen or sulphur; whereat phenylen or heteroarylen group is substituted with (R⁵)_q whereat q is 0 or integer number from 1 to 4 and every R⁵ is independently selected from halogen or (1-4C)alkoxy; t is 0, 1 or 2; n is 0 or integer number from 1 to 3; p is 0 or 1; and R⁷ and R⁸ independently represent hydrogen or (1-4C)alkyl ; or to their pharmaceutically acceptable salts or solvates, or to their stereoisomers. The invention refers also to the pharmaceutical composition, method for preparation of compounds as in any of claims 1-13, to the medicinal preparation as well as to the application of the compounds.

EFFECT: obtaining of new bioactive compounds active as muscarinic receptor antagonists.

27 cl, 34 ex