FIELD: chemistry.
SUBSTANCE: present invention relates to a crystalline salt of 1,2-ethanedisulfonic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinoline-5-yl)ethylamino]methyl} -5- methoxyphenylcarbamoyl)ethyl]piperadin-4-yl ether biphenyl-2-ylcarbamic acid or its solvate. The invention also relates to a pharmaceutical composition containing such a salt, a combination containing the salt in paragraph 1 and a steroid anti-inflammatory agent, a method of treating pulmonary disorder, a method of producing the salt in paragraph 1 and use of the salt in paragraph 1 in making a medicinal agent.
EFFECT: novel crystalline salt of the compound given above, having useful biological properties, is obtained.
34 cl, 6 dwg, 19 ex
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Authors
Dates
2010-02-10—Published
2005-08-15—Filed