CRYSTALLINE FORM OF BIPHENYL COMPOUND Russian patent published in 2010 - IPC C07D401/12 A61K31/4709 A61P11/00 

Abstract RU 2381223 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a crystalline salt of 1,2-ethanedisulfonic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinoline-5-yl)ethylamino]methyl} -5- methoxyphenylcarbamoyl)ethyl]piperadin-4-yl ether biphenyl-2-ylcarbamic acid or its solvate. The invention also relates to a pharmaceutical composition containing such a salt, a combination containing the salt in paragraph 1 and a steroid anti-inflammatory agent, a method of treating pulmonary disorder, a method of producing the salt in paragraph 1 and use of the salt in paragraph 1 in making a medicinal agent.

EFFECT: novel crystalline salt of the compound given above, having useful biological properties, is obtained.

34 cl, 6 dwg, 19 ex

Similar patents RU2381223C2

Title Year Author Number
BIPHENYL DERIVATIVES 2004
  • Mammen Mataj
  • Danem Sara
  • Kh'Juz Adam
  • Li Tae Veon
  • Khasfeld Krejg
  • Stehndzhlehnd Ehrik
  • Chen' Jan'
RU2330841C2
DIAMIDE COMPOUNDS HAVING ACTIVITY OF MUSCARINIC RECEPTOR ANTAGONIST AND ACTIVITY OF β ADRENERGIC RECEPTOR AGONIST 2010
  • Khyuz Adam
  • Biun Deniel
  • Chen Yan
  • Fleri Melissa
  • Dzhekobsen Dzhon R.
  • Stendzhlend Erik L.
  • Uilson Richard D.
  • En Rouz
RU2676686C2
DIAMIDE COMPOUNDS POSSESSING MUSCARINIC ANTAGONIST ACTIVITY AND B2 ADRENERGIC RECEPTOR B2 AGONIST ACTIVITY 2010
  • Kh'Juz Adam
  • Biun Dehniel
  • Chehn' Jan'
  • Fleri Melissa
  • Dzhekobsen Dzhon R.
  • Stehndzhlehnd Ehrik L.
  • Uilson Richard D.
  • En Rouz
RU2543716C2
BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 2005
  • Mammen Mataj
  • Tszi Ju-Khua
  • Mu Juntsi
  • Khasfeld Krejg
  • Li Li
RU2366656C2
DERIVANTS OF BICYCLO[2, 2, 1] HEPT-7-YLAMINE AND THEIR APPLICATIONS 2006
  • Finch Garri
  • Rehj Nikolas Charl'Z
  • Bull Richard Dzhejms
  • Van Nil Monik Bodil
  • Dzhenningz Ehndrju Stefen Robert
RU2442771C2
BENZAMIDE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS OF SAID DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THERE ON AND APPLICATION THEREOF 2004
  • Kuramoti Takakhiro
  • Asai Norio
  • Ikegai Kazukhiro
  • Akamatsu Seidziro
  • Kharada Khironori
  • Isikava Noriko
  • Sirakami Sokhej
  • Mijamoto Satosi
  • Vatanabe Tosikhiro
  • Kiso Tetsuo
RU2333198C2
COMPOUNDS HAVING ANTAGONISTIC ACTIVITY TOWARDS MUSCARINIC RECEPTORS AND AGONIST ACTIVITY TO BETA2-ADRENORECEPTORS 2012
  • Rankati Fabio
  • Linnej Jen
  • Ritstsi Andrea
  • Blekebi Uesli
  • Najt Kris
RU2606121C2
COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA-2-ADRENERGIC RECEPTOR AGONIST ACTIVITY 2013
  • Rancati Fabio
  • Linney Ian
  • Knight Chris
  • Schmidt Wolfgang
RU2661877C2
CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE 2017
  • Ven, Shoumin
  • Gao, Tszejyun
  • Van, Tszyuni
  • Chen, Syaopin
RU2722720C1
DERIVATIVES OF 4-PIPERIDINYLALKYLAMINE AND PHARMACEUTICAL COMPOSITION POSSESSING ANTAGONISTIC AFFECT ON MUSCARINIC RECEPTOR 2002
  • Broterton-Plejss Kristine Eh.
  • Madera Ann Mari
  • Uehjkert Robert Dzhejms
RU2300524C2

RU 2 381 223 C2

Authors

Chao Robert S.

Rapta Miroslav

Kol'Son P'Er-Zhan

Dates

2010-02-10Published

2005-08-15Filed