METHOD OF PREDICTION OF MITOCHONDRIAL MALADIES IN INFANTS WITH UNDIFFERENTIATED FORMS OF NEUROPSYCHIC DELAY (VERSIONS) Russian patent published in 2009 - IPC G01N33/68 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to paediatrics. The method of prediction of mitochondrial maladies in infants with undifferentiated forms of neuropsychic delay is ensured by cytochemical analysis of enzyme strength of biological lymphocytic metabolism in peripheral blood. Further, strength of SDH, GPDH, GDH, MDH, LDH, ratio of GPDH to SDH strength, sigmal deviation of quantitative character of enzyme strength, and age-specific ratio of GPDH to SDH strength are calculated. Or space ratio of all SDH enzyme granules, ellipse index of GPDH clusters, integrated optical density of all GDH granules, area of all small LDH granules and age-specific sigmal deviations of each enzyme index. On the basis of findings, mitochondrial cytochemical factor (MCF) is evaluated. Increase in MCF shows potential development of mitochondrial malady.

EFFECT: accessing the adequate information on energy metabolism state using minimum material required and ensured of sparing (minimally invasive) conditions of the patient's examination.

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