ANTIBACTERIAL AND NECROLYTIC LOCAL LISOAMIDASE PHARMACEUTICAL COMPOSITION Russian patent published in 2009 - IPC A61K38/43 A61K35/66 A61K9/06 A61K9/48 A61P31/04 A61P17/02 

Abstract RU 2367469 C2

FIELD: medicine.

SUBSTANCE: invention is applied for treatment of purulent wounds and burns, pyoinflammatory dermatopathies, and for acceleration of healing and improvement of wound healing conditions. The composition possesses antibacterial and necrolytic action; it contains an active complex of bacteriolytic and proteolytic enzymes - Lisoamidase, and a base for soft formulation of the composition. The base contains a thermally stable perfluororganic compound emulsion with gas-transport properties and mixed hydrophilic substances specified as follows: proxanol-268, polyethylene oxides, propylene glycol, dimexide, hyaluronic acid or sodium hyaluronate, sorbite, glycerine, aerosil. Besides, the composition can contain at least one desired additive chosen from: anaesthetic (Chinoxycaine, Trimecaine, Pyromecaine, Lidocaine or mixed), a reparative process stimulator (methyluracil, acetamine, ethadene, calcium pantothenate, Solcoseryl or mixed) or mixed. The composition is made in the form of ointment or gel, rectal suppositories or capsules.

EFFECT: extended application, enhanced therapeutic activity and ease of use; lower consumption of the active substance; ensured anaesthetising effect; improved microcirculation in wound tissues, managed inflammatory processes, additional stimulation of reparative processes.

6 cl, 2 tbl, 19 ex

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Authors

Beniashvili Allan Gerovich

Blatun Leonid Aleksandrovich

Kogan Vladimir Il'Ich

Kukushkin Nikolaj Il'Ich

Mezhburd Evgenij Vol'Fovich

Sokolov Sergej Dmitrievich

Fesenko Evgenij Evgen'Evich

Dates

2009-09-20Published

2007-05-23Filed