ALKYL-SUBSTITUTED INDOLEQUINOXALINES Russian patent published in 2009 - IPC C07D487/04 A61K31/4985 A61P25/00 A61P37/00 

Abstract RU 2369609 C2

FIELD: medicine.

SUBSTANCE: according to the invention there is provided substituted indolequinoxalines of the formula (I), where R1 represents hydrogen or represents one or more similar or different substituent in positions from 7 to 10, selected of the group of halogen, low alkyl/alkoxy, hydroxy, triflouromethyl, trichloromethyl, triflouromethoxy, R2 represents similar or different C1-C4 alkyl substituents, X represents CO or CH2, Y represents OH, NH2, NH-(CH2)n-R3, where R3 represents low alkyl, OH, NH2, NHR4 or NR5R6, where R4, R5 and R6 represent low alkyl or cycloalkyl independently and n represents integer from 2 to 4 provided that X represents CH2, Y represents OH or NH-(CH2)n-OH and its pharmaceutically acceptable salt. There is also provided pharmaceutical composition, containing these compounds, methods of compound producing, formula (I).

EFFECT: compounds are applied as medicine for treatment and prevention of autoimmune diseases.

15 cl, 1 ex, 5 dwg

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RU 2 369 609 C2

Authors

Bergman Jan

Ehngkvist Robert

Gerdin Bengt

Kilstrom Ingemar

B'Erklund Ul'F

Dates

2009-10-10Published

2005-05-18Filed