5-AMINO-4,6-DISUBSTITUTED INDOLE AND 5-AMINO-4,6-DISUBSTITUTED INDOLINE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS Russian patent published in 2013 - IPC C07D209/22 C07D209/08 A61K31/404 A61P25/08 

Abstract RU 2483060 C2

FIELD: chemistry.

SUBSTANCE: invention refers to compounds of formula I: wherein a dash line represents an optional double bond; R1 means phenyl, naphthyl, pyridyl optionally substituted by one or two substitutes optionally substituted from halogen, C1-C6 alkyl, mono-halo C1-C6 alkyl, di-halo C1-C6 alkyl, CF3; R2 means H, methyl, halogen; R3 and R4 optionally mean, CF3, halo, C1-C3 alkyl wherein C1-C3 alkyl groups are optionally substituted by one or more halogen atoms; X=O; q=0; R5 means C1-C6 alkyl or its pharmaceutically acceptable salt.

EFFECT: compounds possess potassium channel modulating activity that enables using them in pharmaceutical compositions.

28 cl, 1 tbl, 2 dwg

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RU 2 483 060 C2

Authors

Vern'E Zhan-Mishel'

Chen' Khuan'Min

Son Tszian'Lan'

Dates

2013-05-27Published

2008-08-12Filed