TREATING CANCER BY HUMANISED ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR Russian patent published in 2020 - IPC C07K16/28 C07K14/725 C07K19/00 C12N15/63 C12N5/10 C12N5/783 A61P35/00

Abstract RU 2711975 C2

FIELD: medicine.

SUBSTANCE: present invention relates to immunology. Disclosed are an isolated nucleic acid molecule encoding an anti-CD19 chimeric antigen receptor, an isolated anti-CD19 chimeric antigen receptor molecule, as well as a humanized anti-CD19-binding domain. Invention also discloses a vector, cells, a method for producing a cell, a method of producing a population of cells, a method for creating antitumour immunity and a method of treating. Described nucleic acid molecules encoding anti-CD19 CAR are also described.

EFFECT: present invention can find further application in therapy of various proliferative diseases associated with expression of CD19, particularly cancer.

83 cl, 12 dwg, 6 tbl, 6 ex

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RU 2 711 975 C2

Authors

Brogdon Dzhennifer

Dzhun Karl Kh.

Lev Andreas

Maus Marsela

Sholler Dzhon

Dates

2020-01-23—Published

2014-03-15—Filed