OBTAINING OF HOP EXTRACTS, POSSESSING ESTROGENIC AND ANTI-PROLIFERATIVE BIOACTIVITY Russian patent published in 2009 - IPC A61K36/185 A61P35/00 A61P15/12 A61P19/10 A61P5/24 A61P9/10 

Abstract RU 2370273 C2

FIELD: medicine.

SUBSTANCE: hop or hop-product is subjected to isomerisation reaction in presence of water in alkaline medium and at least one extraction, which is carried out by at least one organic solvent, selected from group of alcohols, water-containing alcohols, ketones, water-containing ketones or ethers or their mixtures or alkalised water. Reaction of isomerisation and at least one extraction is continued until obtained is extract which contains 8-prenylnaringenyl, in which (8-prenylnaringenin×100%)/(8-prenylnaringenin+6-prenylnaringenin) ratio constitutes at least 50%. By said method obtained is hop extract, which has estrogenic and anti-proliferative bioactivity. Hop extract is applied for producing medicament in which probable proliferative activity, caused by estrogenic activity of 8-prenylnaringenin, is inhibited or balanced by anti-proliferative activity of xanthogumol. Hop extract is applied for producing medicament for treatment or prevention of one of conditions, symptoms, complaints or diseases, caused by disturbance of hormonal balance of estrogenic nature.

EFFECT: invention allows realisation of said function.

25 cl, 2 tbl, 2 ex

Similar patents RU2370273C2

Title Year Author Number
ENZYMATIC DEMETHYLATION OF FLAVONOIDS 2006
  • Possem'E Sehm
  • Verstrate Villi
  • Khejerik Arne
  • De Kekelejre Denis
RU2449018C2
HOP EXTRACT 2007
  • Onikienko Boris Sergeevich
  • Onikienko Sergej Borisovich
  • Zemljanoj Aleksandr Vasil'Evich
  • Fosman Arkadij Valer'Evich
RU2344167C2
USE OF XANTHOHUMOL AND ISOXANTHOHUMOL AS ACTIVE SUBSTANCE FOR PREVENTING AND/OR CONTROLLING LIVER DISEASES 2007
  • Khellerbrand Klaus
RU2454996C2
PROCESS FOR PREPARATION OF XANTHOHUMOL 2014
  • Gagos Mariush
RU2655926C2
METHOD FOR PRODUCTION OF BEER USING HOP GRAINS CONTAINING STILBENES AND FLAVONOIDS AS ANTIOXIDANTS 2007
  • Zherkovich Vesna
  • Kollen Son'Ja
RU2495099C2
SOLUBILISATE WITH CURCUMIN AND AT LEAST ONE THC CANNABINOID AS AN ADDITIONAL ACTIVE SUBSTANCE 2019
  • Behnam, Dariush
RU2777185C1
SOLUBILIZE WITH CURCUMIN, AND IF NECESSARY AT LEAST WITH ONE OTHER ACTIVE SUBSTANCE 2018
  • Behnam, Dariush
RU2752078C1
SOLUBILISATE WITH CURCUMIN AND AT LEAST ONE CANNABINOID AS AN ADDITIONAL ACTIVE SUBSTANCE 2019
  • Behnam, Dariush
RU2771527C1
BIOLOGICALLY ACTIVE DIETARY SUPPLEMENT "ERAMIN" DIETARY SUPPLEMENT ORIGITEA OMOLOZHENIYE 2010
  • Mukhina Marijat Muradalievna
RU2435453C1
IMPROVED METHOD OF ISOMERISATION OF HOP ALPHA-ACIDS INTO ISO-ALPHA-ACIDS 2011
  • De Vos Dirk
  • Mertens Paskal'
RU2573635C2

RU 2 370 273 C2

Authors

Mas Fransis

De Kekelejre Denis

Khejerik Arne

Dates

2009-10-20Published

2004-12-15Filed