PHENYL SUBSTITUTED PYRROLIDONES Russian patent published in 2009 - IPC C07D207/26 C07D231/56 C07D401/04 C07D403/04 A61K31/4015 A61K31/415 A61P31/18 

FIELD: chemistry.

SUBSTANCE: present invention relates to phenyl substituted pyrrolidones of formula: , where R¹ and R⁵ represent substitutes, which are independently chosen from a group which contains H, CN, halogen, C₁-C₄alkyl and OR⁸, where R⁸ represents C₁-C₄alkyl, R² and R⁴ represent substitutes, which are chosen from a group which contains H, halogen, CN and C₁-C₄alkyl, R³ represents H, R⁶ represents a condensed phenyl heterocyclic ring system, chosen from , where R¹⁶ represents a substitute, chosen from a group which contains H, C(O)NR¹⁸R¹⁹ and S(O)₂R²⁰, where R¹⁸ and R¹⁹ represent H or C₁-C₆alkyl; R²⁰ represents C₁-C₆alkyl or phenyl; and R¹⁷ represents a substitute, which is chosen from a group which contains H, NH₂, (CH₂)_mOH, C(O)NR²¹R²², SO₂R²³ and NHSO₂R²³; where R²¹ and R²² represent substitutes, which are independently chosen from a group which contains H and substituted or unsubstituted C₁-C₆alkyl, or, together with a nitrogen atom to which they are bonded, optionally form a ring; R²³ represents C₁-C₆alkyl; and m equals 1; or R⁶ represents a group, where R⁹ and R¹¹ represent substitutes, which are independently chosen from a group which contains H, halogen, CN, C(O)NR¹²R¹², NR¹²R¹² and OR¹², where each R¹² represents H or C₁-C₄alkyl, and under the condition that, at least one of substitutes R⁹ and R¹¹ is not hydrogen; R¹⁰ represents CN, NR¹³R¹⁴, SO₂NHR¹³, NHSO₂R¹³, O(CH₂)_nSO₂R¹⁵, SO₂R¹⁵, SO₂(CH₂)_nNR¹³R¹⁴ or C(O)NR¹³R¹⁴, where R¹³ and R¹⁴ represent H or C₁-C₄alkyl; R¹⁵ represents C₁-C₄alkyl, n equals 1-2, and R⁷ represents halogen, C₁-C₄alkyl, C₂-C₄alkenyl or C₂-C₄alkynyl.

EFFECT: design of compounds and a pharmaceutical composition for inhibiting HIV growth.

19 cl, 12 ex, 1 tbl