FIELD: chemistry.
SUBSTANCE: invention relates to dihydropyridine derivatives with general formula 
, or their pharmaceutically acceptable salts, where R1 is C1-6alkyl or phenyl, C1-5heteroaryl, both optionally substituted with one or more substitutes, chosen from hydroxy, amino, halogen, nitro, cyano; R2, R3 are independently C1-4alkyl, C1-4alkoxy group, C2-4alkenyloxy group, C3-4alkynyloxy group, halogen; R4 is C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-4alkyl, C6-10aryl, C6-10arylC1-4alkyl, C1-9heteroaryl, where the (hetero)aryl group is optionally substituted with one or more substitutes, chosen from hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy group, C1-4(di)alkylamino group, and, if R4 is a phenyl, additionally from C1-4alkylthio group, C1-4alkylsulphonyl, R5-oxycarbonyl, R5-carbonyl or R5,R6-aminocarbonyl; X is SO2, CH2, C(O) or X is absent, where X is CH2, R4 can additionally represent R5-oxycarbonyl, or R5-carbonyl; R5, R6 are independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C3-6cycloakyl, C3-6cycloalylC1-4alkyl, C2-6heterocycloalkyl, C2-6heterocycloalkylC1-4alkyl, C1-4alkoxycarbonylC1-4alkyl, C1-4(di)alkylaminocarbonylC1-4alkyl or C6-10arylaminocarbonylC1-4alkyl, C1-9heteroarylaminocarbonylC1-4alkyl, C6-10aryl, C1-9heteroaryl, C6-10arylC1-4alkyl, C1-9heteroarylC1-4alkyl, where the (hetero)aryl group is optionally substituted with one or more substitutes, chosen from hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy group, C1-4(di)alkylamino group or R5, R6 in R5, R6- aminocarbonyl group can be bonded to a C2-6heterocycloalkyl ring, as well as to a pharmaceutical composition with antagonistic activity towards FSH receptor and to use of these compounds for making medicinal agents.
EFFECT: compounds which are suitable for treating fertility disorders are obtained and described.
11 cl, 33 ex
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