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2 168 994

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C1

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IPC

(21) (22)

Application

99125536/14, 1999-12-06

(24)

Start date

1999-12-06

(22)

Actual filing date

1999-12-06

(45)

Published

2001-06-20

(72)

Inventor

Shkurupij V.A.Kurunov Ju.N.Pupyshev A.B.Panasenko S.G.Kozjaev M.A.Shorina G.N.

(73)

Holder

Novosibirskaja Gosudarstvennaja Meditsinskaja Akademija

AGENT WITH LOW HEPATOTOXICITY FOR TREATMENT OF TUBERCULOSIS PATIENTS Russian patent published in 2001 - IPC

Abstract RU 2168994 C1

FIELD: organic chemistry, medicine, phthisiology, chemical-pharmaceutical industry. SUBSTANCE: invention proposes an agent that is a conjugate of isoniazide with dextran of molecular mass 65-75 kDa of the following formula: where R1 is H, glucose residue or polyglycosyl residue as given in a drawing; R2 is a residue of isoniazide of the formula: -NH-NH-; R3 is hydroxyl group. EFFECT: decreased hepatotoxicity of antituberculosis agent isoniazide, retained high-therapeutic effectiveness of isoniazide. 2 dwg

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RU 2 168 994 C1

Authors

Shkurupij V.A.

Kurunov Ju.N.

Pupyshev A.B.

Panasenko S.G.

Kozjaev M.A.

Shorina G.N.

Dates

2001-06-20—Published

1999-12-06—Filed

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