FIELD: medicine.
SUBSTANCE: there is described hydroxyethyl starch of average molecular weight Mw more or equal to 500000, differing that molar fractional substitutionality MS makes 0.25 to 0.5 and C2/C6 relation is 2 to less than 8, the based pharmaceutical composition, application of this pharmaceutical composition to make plasma substitute or plasma extender, and also application of this pharmaceutical composition to maintain normovolemia and/or to improve macro- and microcirculation, and/or to improve trophic oxygen supply, and/or to stabilise hemodynamics, and/or to improve volumetric efficiency, and/or to reduce plasma viscosity, and/or to increase anaemia tolerance, and/or for hemodilution, particularly for therapeutic hemodilution in blood supply disturbance and arterial, especially peripheral arterial obliterating diseases. There is also described method for making said hydroxyehtyl starch that implies transformation of water-suspended starch with ethylene oxide and the following partial hydrolysis of the prepared derivative starch by acid to the required range of molecular weights of hydroxyehtyl starch.
EFFECT: hydroxyehtyl starch of low propensity to cumulation and low effect on coagulation and simultaneously prolonged half-life.
27 cl, 1 dwg, 7 tbl, 3 ex
