A CONJUGATE OF HYDROXYALKYL STARCH AND LOW-MOLECULAR SUBSTANCE AND METHOD OF OBTAINING IT Russian patent published in 2008 - IPC C08B31/12 C08B31/18 A61K47/48 A61K47/36 

FIELD: chemistry; medicine.

SUBSTANCE: description is given of a conjugate of hydroxyalkyl starch and a low-molecular substance, in which the binding interaction between the molecular hydroxyalkyl starch and the low-molecular substance is based on a covalent bond, which forms from a bonding reaction between (i) an end aldehyde group or carboxyl group, formed due to selective oxidation of the end aldehyde group, or activated carboxyl group, obtained from conversion of the carboxyl group of hydroxyalkyl starch molecules and (ii) a functional group of a low-molecular substance, chosen from a group, consisting of an amino group, carboxyl group, thiol group and a hydroxyl group, which is reactive, relative the given aldehyde group or carboxyl group or an activated carboxyl group of hydroxyalkyl starch molecules. The bond directly formed from the bonding reaction can be modified for further reaction until formation of the above mentioned covalent bond, if necessary.

EFFECT: use of the conjugate allows for increasing duration of the presence of the low-molecular substance in blood plasma.

35 cl, 29 ex