METHOD OF ANTICALCIUM TREATMENT OF BIOLOGICAL PROSTHESES OF HEART VALVES Russian patent published in 2009 - IPC A01N1/02 A61F2/24 A61L27/50 A61L33/04 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to cardio-vascular surgery, and can be used in manufacturing bioprostheses intended for heart valve prosthetics. Essence of invention lies in the following: after conservation with epoxy compound, such as 2-5% solution of ethylene glycol diglycidyl ether, during 2-21 days biomaterial is washed in 0.9% sodium chloride solution and treated with 0.05-1.0% solution of 3-amino-1-oxypropylidene-1,1-diphosphonic acid (DP), prepared on phosphate buffer pH 4.0-8.0. Treatment is carried out at temperature 5-40°C. After treatment biomaterial is washed from non-bound DP and placed into sterilising solution for storage. Application of DP as anticalcium agent gives epoxy-treated biomaterial additional resistance to calcification.

EFFECT: invention ensures increase of treatment efficiency due to reduction of calcium-binding activity of biological prostheses for cardio-vascular surgery.

2 cl, 1 tbl, 1 ex