FIELD: medicine.
SUBSTANCE: claimed invention relates to field of medications, in particular to solid compositions used to improve water-solubility of pharmaceutically active ingredient, including (1) pharmaceutically active ingredient represents diethyl ether of 2-(2-{3-dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetoxymethyl)-2-phenylmalonic acid or its salt, (2) water-soluble polymer substance (polyvinylpyrrolodone or hydroxypropylcellulose) (3) inorganic porous (water-free silicic acid), and pharmaceutically active ingredient forms solid dispersion in form of particles together with water-soluble polymer substance, and water-soluble polymer substance in form of particles is supported in state in which it is able to be adsorbed and/or to stick to surface of inorganic porous substance. Invention also relates to method of obtaining said compositions.
EFFECT: such compositions ensure improvement of active component solubility and improve stability.
22 cl, 2 dwg, 2 tbl, 6 ex
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