PIPERAZINE COMPOUND INHIBITING PROSTAGLANDIN-D-SYNTHASE Russian patent published in 2013 - IPC C07D401/12 C07D401/14 C07D403/14 A61K31/496 A61K31/5377 A61P11/06 A61P29/00 A61P37/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a piperazine compound presented by formula , wherein R¹ represents C_1-6 alkyl; R² represents hydroxy, C_1-6 alkyl which can contain a substitute specified in saturated or unsaturated 5-6 member heterocycle with 1-3 heteroatoms specified in oxygen and nitrogen, -(C=O)-N(R³)(R⁴) or -(C=O)-OR⁵; R³ and R⁴ may be identical or different, and each represents hydrogen or C_1-6 alkyl which can contain a substitute specified in saturated or unsaturated 5-6 member heterocycle with 1-3 heteroatoms specified in oxygen and nitrogen, or R³ and R⁴ bound through a nitrogen atom whereto R³ and R⁴ are attached, can form a saturated heterocyclic group specified in 5-6 member heterocycle with 1-3 heteroatoms specified in oxygen and nitrogen; R⁵ represents hydrogen or C_1-6 alkyl; and n represents 1 or 2; or a salt thereof. Also, the invention refers to a pharmaceutical compositions and an agent exhibiting prostaglandin-D-synthase activity and based on the compound of formula I, as well as to a method of preventing and treating a disease wherein prostaglandin D2 is involved.

EFFECT: there are prepared and described new compounds which may be effective in treating the diseases wherein prostaglandin D2 is involved.

11 cl, 19 ex, 4 tbl