FIELD: chemistry.
SUBSTANCE: sertraline hydrochloride and its crystalline polymorphous forms are known and used, for example for treating depression, obsessive-compulsive and panic disorders, as well as for monitoring food products. The method of producing crystalline polymorphous forms of sertraline hydrochloride involves the following steps: a) suspending/dissolving sertraline acetate in organic solvents, selected from methanol, ethanol, isopropanol, toluene or their mixture, or in water; b) setting pH of the mixture to a value between 1 and 2 using hydrogen chloride at temperature ranging from 40 to 65°C, or 25°C; c) cooling the reaction mixture, d) separation and drying. According to the method, crystalline polymorphous forms II, III, IV and V can be obtained by varying conditions for cooling, separation and drying.
EFFECT: method is economically effective and is suitable for large-scale production of different polymorphous forms of sertraline hydrochloride.
12 cl, 3 tbl, 6 ex
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