FIELD: chemistry.
SUBSTANCE: invention relates to an improved method of producing 2H-1-benzopyran-2-methanol-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-[2R*[R*[R*(S*)]]]], i.e. a nebivolol base of formula (IX), or its hydrochloride salt 
as well as to a method of producing an intermediate compound - benzylated nebivolol of formula (VIII), 
EFFECT: invention also relates to a pharmaceutical composition with antihypertensive action without using a wetting agent, and to a tablet containing this pharmaceutical composition.
21 cl, 20 tbl, 21 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS CONTAINING FINELY GROUND NEBIVOLOL | 1995 |
|
RU2137473C1 |
| METHOD OF NEBIVOLOL RACEMATE OBTAINMENT | 2006 |
|
RU2392277C2 |
| PHARMACEUTICAL COMPOSITION | 2012 |
|
RU2630617C2 |
| NOVEL SALT | 1998 |
|
RU2193560C2 |
| PHARMACEUTIC COMPOSITION, WHICH CONTAINS HYDROXYLATED NEBIVOLOL | 2006 |
|
RU2433823C2 |
| DIHYDROBENZOPYRANE DERIVATIVES WITH VASOCONSTRICTIVE EFFECT, INTERMEDIATE COMPOUNDS, PREPARATION METHODS, PHARMACEUTICAL COMPOSITION, METHOD OF PREPARING THEREOF | 1994 |
|
RU2129556C1 |
| COMBINATION OF REUPTAKE INHIBITOR OF 5-HT WITH SELECTIVE 5-HT ANTAGONIST | 1996 |
|
RU2183955C2 |
| BENZOPYRANS, PHARMACEUTICAL COMPOSITION BASED THEREON, AND METHOD OF MEDICAL TREATMENT | 1995 |
|
RU2147581C1 |
| COMPOUNDS (R)-5-CARBAMOYL-8-FLUORO-3,N,N-DISUBSTITUTED AMINO-3,4-DIHYDRO-2H-1-BENZOPYRANES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT OF PATIENTS AND METHODS OF SYNTHESIS OF COMPOUNDS | 1994 |
|
RU2142951C1 |
| PHARMACEUTICAL DOSED FORMULATION FOR DELIVERY THROUGH MUCOSA | 2003 |
|
RU2285520C2 |
