METHOD OF PRODUCING SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 Russian patent published in 2016 - IPC C07D213/61 C07D401/04 C07C315/02 

Abstract RU 2591848 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a novel method of producing 5-chloro-3-(4-methylsulphonyl) phenyl-2-(2-methyl-5-pyridinyl)pyridine (Etoricoxib), involving oxidation of 5-chloro-3-(4-methylthio) phenyl-2-(2-methyl-5-pyridinyl)pyridine in presence of catalyst of oxidation and interphase transport catalyst to obtain Etoricoxib.

EFFECT: technical outcome is novel simple and efficient method of producing Etoricoxib-selective inhibitor of cyclooxygenase-2.

20 cl, 29 ex, 4 dwg

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RU 2 591 848 C2

Authors

Shakh Dkharmesh Makhendra

Solanki Sandzhaj Amratlal

Dzharivala Viral Narendra

Vias Ashok Vasantraj

Mistri Ashokkumar Bkhikkhubkhaj

Dates

2016-07-20Published

2011-11-15Filed