2-ALKYLAMINO-3-ARYLSULPHONYLCYCLOALKANO [e OR d]PYRAZOLO[1,5-a] PYRIMIDINES SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS FOR MAKING AND APPLYING THEREOF Russian patent published in 2009 - IPC C07D487/04 A61K31/519 A61P25/28 A61P25/18 A61P25/26 

FIELD: pharmacology.

SUBSTANCE: invention refers to new 2-alkylamino-3-arylsulphonylcycloalkano[e]pyrazolo[1,5-a]pyrimidines of general formula 1 and 2-alkylamino-3-arylsulphonylcycloalkano[d]pyrazolo[1,5-a]pyrimidines of general formula 2 with properties of serotonin 5-NT₆ receptor antagonists, to pharmaceutical compositions containing specified compounds as a principle, medical products and method of treatment and the prevention of CNS diseases. In general formulae 1 and 2, R¹ represents hydrogen atom or C₁-C₃ alkyl; R² represent C₁-C₃ alkyl; R³ represent hydrogen atom, one or two optionally substituted identical halogen atoms, C₁-C₃ alkyl or hydroxyl optionally substituted with C₁-C₃alkyl; n represents an integer 1, 2 or 3. The invention also relates to the method for making the compounds of general formula 1 or 2 by interaction of 3-amino-4-arylsulphonyl-2H-pyrazoles of general formula 3 with relevant β-dicarbonyl compounds of general formula 4 or their derivatives of general formula 5. 3, 4, 5, where: R¹, R², R³ and n have said values.

EFFECT: new 2-alkylamino-3-arylsulphonyl-cycloalkano[e or c1]pyrazolo[1,5]pyrimidines - serotonin 5-NT₆ receptor antagonists, methods of making and applying thereof.

12 cl, 1 dwg, 4 tbl, 9 ex