TREATMENT OF BACTERIAL INFECTIONS Russian patent published in 2009 - IPC C07K16/12 A61K39/395 

FIELD: pharmacology.

SUBSTANCE: invention concerns biotechnology. There is described application of antibody to acetyl-CoA-acetyltransferase or its antigen-binding fragment in manufacturing of a medical product for treatment or prevention of the infection caused by Clostridium difficile and Enterococcus faecalis, faecium is described. There is disclosed combined preparation for treatment of the infection caused by Clostridium difficile containing (i) antibody to acetyl-CoA-acetyltransferase or its antigen-binding fragment; and (ii) at least one antibiotic from the group consisting of gentamycin, vancomycin and metronidazole. There is presented inhibitor of acetyl-CoA-acetyltransferase representing antibody or its antigen-binding fragment, containing at least one component of the group consisting of (i) complementarity determining regions (CDR) of 1-3 VH-chain; and (ii) complementarity determining regions (CDR) of 3 VL-chain. There is described method of treating the infection caused by Clostridium difficile, including introduction of therapeutically effective amount of antibody to acetyl-CoA-acetyltransferase to the medically indigent patient.

EFFECT: invention allows for prevention and treatment of the infection caused by bacteria Clostridium difficile and Enterococcus faecalis, faecium.

43 cl, 6 tbl