ANTIBODIES FOR SPECIFIC BINDING OF STAPHYLOCOCCUS AUREUS ALPHA-TOXIN AND METHODS OF APPLICATION Russian patent published in 2017 - IPC A61K39/40 C07K16/00 A61K39/85 C12P21/08 

FIELD: medicine, pharmacy.

SUBSTANCE: invention refers to biochemistry. An isolated antibody or antigen binding fragment thereof is described. The antibody or its antigen binding fragment is immunospecifically bound to the polypeptide of Staphylococcus aureus alpha-toxin and include CDR1 VH, comprising the amino acid sequence SEQ ID NO: 7, 10, 13 or 69; CDR2 VH, comprising the amino acid sequence SEQ ID NO: 8, 11, 14, 17, 70 or 75; CDR3 VH, comprising the amino acid sequence SEQ ID NO: 9, 12, 15, 18, 16, 65, 66, 67, 71, 72, 76 or 78; CDR1 VL, comprising the amino acid sequence SEQ ID NO: 1 or 4; CDR2 VL, comprising the amino acid sequence SEQ ID NO: 2, 5, 73 or 77; and CDR3 VL, comprising the amino acid sequence SEQ ID NO: 3, 6, 64, 68 or 74. A set and composition for prevention, control or treatment of pneumonia and a method for prevention or treatment of pneumonia are also described.

EFFECT: invention expands the arsenal of tools for pneumonia treatment.

12 cl, 27 dwg, 11 tbl, 14 ex