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(19)

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2 378 269

(13)

(51)

IPC

C07D401/12(2006-01-01)

C07D401/14(2006-01-01)

A61K31/4375(2006-01-01)

A61K31/4725(2006-01-01)

A61K31/506(2006-01-01)

A61P11/06(2006-01-01)

(21) (22)

Application

2007126745/04, 2005-12-14

(24)

Start date

2005-12-14

(22)

Actual filing date

2005-12-14

(45)

Published

2010-01-10

(72)

Inventor

Gabos BalintLundkvist Mikaehl'Munk Af Rozenshel'D MagnusShamovski Igor'Zlatojdski Pavol

(73)

Holder

Astrazeneka Ab

NOVEL HYDANTOIN DERIVATIVES AS METALLOPROTEINASE INHIBITORS Russian patent published in 2010 - IPC C07D401/12 C07D401/14 A61K31/4375 A61K31/4725 A61K31/506 A61P11/06

Abstract RU 2378269 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to novel hydantoin derivatives of formula or pharmaceutically acceptable salt thereof, where R¹ is H, halogen, CF₃ or CH₂CN; R² is C_1-3alkyl; each of A, A¹ and B independently represents CH or N. The invention also relates to a method for synthesis of a formula I compound, to a pharmaceutical composition based a formula I compound and use thereof in making a medicinal agent.

EFFECT: obtaining novel hydantoin derivatives with inhibitory activity towards metalloproteinase.

10 cl, 1 tbl, 6 ex

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RU 2 378 269 C2

Authors

Gabos Balint

Lundkvist Mikaehl'

Munk Af Rozenshel'D Magnus

Shamovski Igor'

Zlatojdski Pavol

Dates

2010-01-10—Published

2005-12-14—Filed