FIELD: medicine.
SUBSTANCE: invention is related to new derivatives of hydantoin with common formula I 
, where R1 represents cyclobutyl or cyclopropyl; where mentioned group cyclopropyl may be additionally substituted with CH3; R2 represents C1-3alkyl or cyclopropyl; and A, A1 and B independently represent CH or N. Invention is also related to method for production of compounds of formula I, pharmaceutical composition on its basis, its use for making of medicinal agent and to method for inhibition of metal proteinases, based on use of compound of formula I.
EFFECT: new derivatives of hydantoin have activity of metal proteinase inhibitor.
11 cl, 1 tbl, 9 ex
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