Show metadata Hide metadata

(19)

(11)

2 378 373

(13)

(51)

IPC

C12N15/08(2006-01-01)

A61K35/14(2006-01-01)

A61K39/04(2006-01-01)

A61P31/06(2006-01-01)

(21) (22)

Application

2008104232/13, 2008-02-04

(24)

Start date

2008-02-04

(22)

Actual filing date

2008-02-04

(45)

Published

2010-01-10

(72)

Inventor

Sennikov Sergej Vital'EvichJakushenko Elena VladimirovnaShevchenko Julija AleksandrovnaLaushkina Zhanna AleksandrovnaSvistel'Nik Andrej VladimirovichKozlov Vladimir Aleksandrovich

(73)

Holder

Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatel'Skij Institut Klinicheskoj Immunologii So RamnFederal'Noe Gosudarstvennoe Uchrezhdenie Novosibirskij Nauchno-Issledovatel'Skij Institut Tuberkuleza Federal'Nogo Agentstva Po Vysokotekhnologichnoj Meditsinskoj Pomoshchi

METHOD FOR GENERATION OF ANTIGEN-SPECIFIC ANTITUBERCULOUS CELLS Russian patent published in 2010 - IPC C12N15/08 A61K35/14 A61K39/04 A61P31/06

Abstract RU 2378373 C2

FIELD: medicine.

SUBSTANCE: according to the invention, the method provides combined cultivation of nonadherent fraction of mononuclear cells (MNCs) recovered from peripheral blood of the patients with pulmonary tuberculosis, with dendritic cells (DCs) processed with the antigen Mycobacterium tuberculosis and prepared of monocytes of adherent MNC fraction with using mature DCs being prepared by adding a maturing inducer representing lipopolysaccharide E coli to antigen-activated immature DCs. The combined cultivation of specified cells is carried out with recombinant human interleukine-18 (IL-18) added.

EFFECT: intensified proliferative potential of specific cytotoxic cells of mononuclear origins, stimulation of IFN -γ production level, formation of cytotoxic cells in response to the specific antigen M tuberculosis.

3 tbl

Similar patents RU2378373C2

Title	Year	Author	Number
METHOD OF GENERATION OF ANTIGEN-SPECIFIC CYTOTOXIC CELLS ACTIVE AGAINST HEPATITIS B INFECTED CELLS	2008	Sennikov Sergej Vital'Evich Jakushenko Elena Vladimirovna Khripko Ol'Ga Pavlovna Kozlov Vladimir Aleksandrovich	RU2366707C1
GENERATION METHOD OF ANTIGEN-SPECIFIC CYTOTOXIC CELLS WITH ACTIVITY AGAINST OVARIAN CARCINOMA CELLS	2012	Sennikov Sergej Vital'Evich Obleukhova Irina Aleksandrovna Kurilin Vasilij Vasil'Evich Krasil'Nikov Sergej Ehduardovich Tarkhov Aleksandr Valer'Evich Goncharov Maksim Aleksandrovich	RU2508298C2
METHOD OF GENERATING ANTIGEN-SPECIFIC OF CYTOTOXIC CELLS WITH ANTICANCER ACTIVITY	2011	Sennikov Sergej Vital'Evich Kurilin Vasilij Vasil'Evich Obleukhova Irina Aleksandrovna Lopatnikova Julija Anatol'Evna Jakushenko Elena Vladimirovna Jakushenko Vladimir Konstantinovich	RU2458985C1
METHOD OF GENERATING ANTIGEN-SPECIFIC CYTOTOXIC CELLS WITH ANTITUMOUR ACTIVITY IN BREAST CANCER	2013	Sennikov Sergej Vital'Evich Shevchenko Julija Aleksandrovna Khantakova Julija Nikolaevna Kurilin Vasilij Vasil'Evich Lopatnikova Julija Anatol'Evna Sidorov Sergej Vasil'Evich Volgushev Sergej Anatol'Evich Ogloblin Vladimir Petrovich Efimova Lina Viktorovna Teplova Nadezhda Veniaminovna	RU2521506C1
METHOD FOR GENERATION OF SPECIFIC IMMUNE RESPONSE ON HUMAN IMMUNODEFICIENCY VIRUS ANTIGENS	2011	Sennikov Sergej Vital'Evich Kurilin Vasilij Vasil'Evich Lopatnikova Julija Anatol'Evna Karpenko Larisa Ivanovna Il'Ichev Aleksandr Alekseevich Kozlov Vladimir Aleksandrovich	RU2465324C1
METHOD OF INDUCING CYTOTOXIC ANTI-TUMOUR IMMUNE RESPONSE in vitro WITH USING DENDRITIC CELLS, TRANSFECTED BY RNA TUMOUR CELLS, TO NON-SMALL CELL LUNG CANCER	2015	Sennikov Sergej Vitalevich Obleukhova Irina Aleksandrovna Lopatnikova Julija Anatolevna Vitsin Aleksandr Evgenevich Kozlov Vadim Viktorovich Kirjushina Natalja Anatolevna	RU2578008C1
METHOD OF GENERATING CYTOTOXIC CELLS WITH ACTIVITY AGAINST NON-SMALL CELL LUNG CANCER CELLS	2014	Sennikov Sergej Vitalevich Obleukhova Irina Aleksandrovna Lopatnikova Julija Anatolevna Vitsin Aleksandr Evgenevich Kozlov Vadim Viktorovich	RU2577992C2
METHOD OF PRODUCING ANTIGEN-SPECIFIC CYTOTOXIC CELLS HAVING ACTIVITY AGAINST BREAST CANCER CELLS	2013	Sennikov Sergej Vitalevich Shevchenko Yuliya Aleksandrovna Khantakova Yuliya Nikolaevna Kurilin Vasilij Vasilevich Lopatnikova Yuliya Anatolevna Sidorov Sergej Vasilevich Zajtsev Sergej Alekseevich Maksyutov Amir Zakievich Gavrilova Elena Vasilevna Maksyutov Rinat Amirovich	RU2596920C2
METHOD FOR OBTAINING ANTIGEN SPECIFIC CYTOTOXIC CELLS WITH ANTI-TUMOR CYTOTOXIC ACTIVITY AGAINST CELLS OF NON-SMALL CELLS LUNG CANCER	2016	Sennikov Sergej Vitalevich Lopatnikova Yuliya Anatolevna Obleukhova Irina Aleksandrovna Kiryushina Natalya Anatolevna Kozlov Vadim Viktorovich	RU2639514C1
METHOD FOR PRODUCTION OF IN VITRO POPULATIONS OF ACTIVATED ANTIGENSPECIFIC ANTITUMOR-TUMOR CYTOTOXIC T-LYMPHOCYTES SPECIFIC TO TUMOR-ASSOCIATED ANTIGEN EPITOPES	2016	Sennikov Sergej Vitalevich Lopatnikova Yuliya Anatolevna Kuznetsova Mariya Sergeevna Maksyutov Amir Zakievich Khantakova Yuliya Nikolaevna Kulikova Ekaterina Vladimirovna	RU2619186C1

RU 2 378 373 C2

Authors

Sennikov Sergej Vital'Evich

Jakushenko Elena Vladimirovna

Shevchenko Julija Aleksandrovna

Laushkina Zhanna Aleksandrovna

Svistel'Nik Andrej Vladimirovich

Kozlov Vladimir Aleksandrovich

Dates

2010-01-10—Published

2008-02-04—Filed