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2 465 324

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IPC

C12N5/71(2010-01-01)

C12N7/00(2006-01-01)

A61K39/00(2006-01-01)

(21) (22)

Application

2011124688/10, 2011-06-16

(24)

Start date

2011-06-16

(22)

Actual filing date

2011-06-16

(45)

Published

2012-10-27

(72)

Inventor

Sennikov Sergej Vital'EvichKurilin Vasilij Vasil'EvichLopatnikova Julija Anatol'EvnaKarpenko Larisa IvanovnaIl'Ichev Aleksandr AlekseevichKozlov Vladimir Aleksandrovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Institut Klinicheskoj Immunologii" Sibirskogo Otdelenija Rossijskoj Akademii Meditsinskikh Nauk So Ramn)

METHOD FOR GENERATION OF SPECIFIC IMMUNE RESPONSE ON HUMAN IMMUNODEFICIENCY VIRUS ANTIGENS Russian patent published in 2012 - IPC C12N5/71 C12N7/00 A61K39/00

Abstract RU 2465324 C1

FIELD: medicine.

SUBSTANCE: what is presented is a method for modulation of a specific immune response on human immunodeficiency virus antigens. Dendritic cells recovered from peripheral blood of nominally healthy donors and presenting specific antigens (polyepitope protein TBI) are cultured with a non-adherent fraction of mononuclear cells with the presence of anti-inflammatory cytokines rhIL-12 and rhIL-18.

EFFECT: method enables producing in vitro antigen-specific clones of T-cells with activity of type 1 T-helpers required to form an effective immune response on HIV antigens.

3 dwg

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RU 2 465 324 C1

Authors

Sennikov Sergej Vital'Evich

Kurilin Vasilij Vasil'Evich

Lopatnikova Julija Anatol'Evna

Karpenko Larisa Ivanovna

Il'Ichev Aleksandr Alekseevich

Kozlov Vladimir Aleksandrovich

Dates

2012-10-27—Published

2011-06-16—Filed