CYCLIC AMINE COMPOUND Russian patent published in 2010 - IPC C07D471/04 C07D491/48 C07D495/04 A61K31/407 A61K31/4355 A61K31/437 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel cyclic amine compounds of formula (1) or pharmaceutically acceptable salts thereof: . In formula (1), X is O, S, NR² (where R² is H, C₁-C₁₂ alkyl); when X is O, S, then R¹ is H, CN, COOH, C₂-C₁₃ alkoxycarbonyl, carbamoyl group; and when X is NR² (where R² assumes values given above), R¹ is CN; Ar¹ and Ar² are identical or different and each represents an aryl which can be substituted with 1-3 halogens; or Ar¹ and Ar² together with neighbouring carbon atoms to which they are bonded form a group with formula (b): (where ring S and ring T are identical and each is a benzene ring; Y is O); ring B is a benzene ring which can be substituted with 1-3 substitutes independently selected from a group comprising halogen, C₁-C₁₂ alkyl, C₁-C₈ halogenalkyl, C₁-C₁₂ alkoxy, C₁-C₈ halogenalkoxy group; n is an integer from 1 to 10; p, q are identical or different and each is an integer equal to 1 or 2. Formula (1) compounds are bonding inhibitors of the α2C-adrenoreceptor.

EFFECT: possibility of using compounds in pharmaceutical compositions.

7 cl, 1 tbl, 8 ex