FIELD: medicine, pharmaceutics.
SUBSTANCE: presented invention refers to immunology. There are presented versions of antibodies neutralising a subtype group 1 and subtype group 2 influenza A virus infection. The antibody is characterised by: either a set of 3 CDR of a light and 3 CDR of a heavy chain, or the presence of variable regions of the light and heavy chains. There are disclosed: a nucleic acid molecule coding the antibody; a cell expressing the antibody; as well as a method for the attenuation of the influenza A virus infection or reducing a risk thereof with the use of the antibody in a therapeutically or preventatively effective amount.
EFFECT: using the invention provides the antibodies neutralising the influenza A virus, which can find application in medicine in treating subtypes H1, H2, H3, H5, H7, H9 influenza.
18 cl, 6 tbl, 2 ex
Title | Year | Author | Number |
---|---|---|---|
IMMUNOGENIC EPITOPE OF INFLUENZA VIRUS | 2009 |
|
RU2546872C2 |
ANTIBODIES SUITABLE FOR PASSIVE IMMUNIZATION AGAINST INFLUENZA, AND COMPOSITIONS THEREOF, COMBINATIONS AND METHODS OF USING | 2015 |
|
RU2720282C1 |
STRAIN OF A RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN ADENOVIRUS GENOME OF SEROTYPE 5 Ad5-tetOFF-E3-HA125 SEROTYPE, CARRYING HAEMAGGLUTININ CONSENSUS GENE OF INFLUENZA VIRUS SUBTYPES H1, H2, H5 FOR PRODUCING INFLUENZA IMMUNOGENIC PREPARATIONS, METHOD FOR PRODUCING GENE | 2018 |
|
RU2713722C1 |
NEUTRALIZING ANTIBODIES TO INFLUENZA VIRUS B AND WAYS FOR APPLICATION THEREOF | 2015 |
|
RU2711932C2 |
NEUTRALIZING BINDING MOLECULES DIRECTED AGAINST INFLUENZA VIRUS, AND METHODS OF THEIR APPLICATION | 2016 |
|
RU2721706C2 |
OBTAINING VIRUS-LIKE PARTICLES OF INFLUENZA VIRUS IN PLANTS | 2014 |
|
RU2742607C1 |
EXPRESSION VECTOR BASED ON HUMAN ADENOVIRUS 5 SEROTYPE, INDUCING CROSS-PROTECTIVE IMMUNITY TO INFLUENZA A VIRUSES OF SUBTYPE H1, AND A PHARMACEUTICAL COMPOSITION BASED ON IT | 2023 |
|
RU2802753C1 |
OBTAINING VIRUS-LIKE PARTICLES OF INFLUENZA VIRUS IN PLANTS | 2014 |
|
RU2705555C2 |
H7N9 INFLUENZA A THERAPY | 2015 |
|
RU2682049C2 |
NEUTRALIZING ANTIBODIES TO INFLUENZA VIRUS B AND WAYS OF THEIR APPLICATION | 2015 |
|
RU2739952C2 |
Authors
Dates
2015-06-10—Published
2009-07-27—Filed