FIELD: chemistry.
SUBSTANCE: there is described a single-step method for synthesis of 1-(β-phenylethyl)-4-(para-dimethylaminobenzylidenamino)-1,2,4-triazole bromide with high output without release of intermediate products using one solvent. In accordance with the described method, 4-amino-1,2,4-triazole is dissolved in butanol, a solution of β-bromoethylbenzene is added to the butanol, the mixture is boiled for 6-8 hours, cooled to 50-60°C, a solution of para-dimethylaminobenzaldehyde is added, as well as a catalytic amount of concentrated hydrobromic acid, the mixture is kept at 50-60°C for 3-5 hours with subsequent cooling to room temperature; the precipitate is filtered, washed with diethyl ether or butanol and dried in air.
EFFECT: design of an efficient method of producing heterocyclic compounds.
2 cl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 1-(β-PHENYLETHYL)-4-(PARA-DIMETHYLAMINOBENZYLIDENEAMINO)- -1,2,4-TRIAZOLIUM BROMIDE SHOWING ANTIOXIDANT, ANTI-ISCHEMIC, β-ADRENOBLOCKING, UTEROTONIC AND DECREASING INTRAOCULAR PRESSURE EFFECTS | 1997 |
|
RU2136669C1 |
| 1-PENTYL-4-(PARA-METHOXYBENZYLIDENEAMINO)-1,2,4-TRIAZOLIUM BROMIDE ELICITING SPASMOLYTIC ACTIVITY | 1997 |
|
RU2131422C1 |
| 1-(β-PHENYLETHYL)-4-AMINO-1,2,4-TRIAZOLIUM BROMIDE (MT) | 2008 |
|
RU2404974C2 |
| SUBSTITUTED DERIVATIVES OF AZOLONE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING | 1994 |
|
RU2128659C1 |
| STEREOISOMERS OF ITRACONAZOLE AND SUPERCONAZOLE, METHOD OF THEIR SYNTHESIS, THEIR COMPLEXES AND PHARMACEUTICAL COMPOSITION BASED ON IT | 1993 |
|
RU2127733C1 |
| METHOD OF REPROCESSING NON-REACTED PRODUCTS IN THE PROCESS OF VITAMIN B SYNTHESIS | 1991 |
|
RU2006496C1 |
| METHOD FOR PRODUCTION OF 5-AMINO-1,2,4-TRIASOL-3-YLCARBOXYLIC ACID OR 5-AMINO-1,2,4-TRIASOL-3-YLACETIC ACID ESTERS | 2004 |
|
RU2269521C1 |
| DERIVATIVES OF 4-QUINOLINYL SHOWING ANTI-HELICOBACTERIAL ACTIVITY, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING THEIR AND METHOD OF ITS PREPARING | 1993 |
|
RU2130933C1 |
| DERIVATIVES OF 1,2,4-TRIAZOLYLTHIOAMIDES | 1990 |
|
RU2045521C1 |
| METHOD OF PRODUCING 1-[DI (4-CYANOPHENYL)METHYL]-1,2,4-TRIAZOLE | 2009 |
|
RU2425038C2 |
