SUBSTITUTED DERIVATIVES OF AZOLONE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to synthesis of drugs used for treatment of patients infected with Helicobacter. Invention proposes compounds of the formula (I), their pharmaceutically acceptable salts with acids or their stereochemical isomers where X and Y each means independently CH or N; R¹, R² and R³ each means independently hydrogen atom or C₁-C₄-alkyl; R⁴ and R⁵ each independently hydrogen, halogen atom, C₁-C₄--alkyl, C₁-C₄--alkoxy-group, hydroxy-group, trifluoromethyl-group, trifluoromethoxy-group or difluoromethoxy-group; Z means C=O or CHOH and Ar means phenyl possibly substituted with up to three substituents taken from hydroxy-group, C₁-C₄--alkyl, C₁-C₄--alkoxy-group, halogen atom, trifluoromethyl-group, tri-(C₁-C₄--alkyl)-silylhydroxy- -group, or pyridinyl substituted with hydroxy-group and C₁-C₄--alkylhydroxy-group; (A) means radical of the formulas (a-1), (a-2), (a-3), (a-4), (a-5). Invention describes a method of their synthesis and a pharmaceutical preparation containing derivatives of azolone of the formula (I) as an active component and a method of its preparing. EFFECT: improved method of synthesis. 5 cl, 1 tbl, 25 ex