FIELD: medicine.
SUBSTANCE: invention refers to an acid addition dopenzil salt [(±)-2-[(1-benzyl-4-piperidinyl)mathyl]-5,6-dimehoxy-1-indanone] of general formula (II), 
where X stands for a radical of fumaric acid prepared by reaction of dopenzil base and fumaric acid in ethanol or 2-propanol as a solvent, separation of dopenzil salt produced thereby and optionally washings with an organic solvent. The invention also concerns a pharmaceutical composition, the method of preparing the pharmaceutical compositions, application of acid addition dopenzil salt, and also the method for prevention or treatment of the diseases.
EFFECT: preparation of new acid addition dopenzil salt which is applicable for prevention or treatment of the diseases associated with acetylcholine lack in brain, Alzheimer's disease or senile psychosis.
8 cl, 12 ex
| Title |
Year |
Author |
Number |
| 2-PHENYL-2-METHYLAMINOETHOXY-1,7,7-TRIMETHYL-BICYCLO[2,2,1]HEPTANE, ITS OPTICALLY ACTIVE ISOMERS AND PHARMACEUTICALLY ACCEPTABLE SALTS FOR PHARMACEUTICAL COMPOSITIONS, METHODS OF THEIR SYNTHESIS (VERSIONS), PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING |
1997 |
- Gachaji Ishtvan
- Klebovich Imre
- Budai Zoltan
- Lukach D'Jula
- Kaufmanne Bojti Ehrzhebet
- Shmidt Eva
- D'Ert'Jan Ishtvan
- Bilkei Gorzo Andrash
- Blashko Gabor
- Abermann Miklosh
- Balogne Nemesh Katalin
- Grezal D'Jula
- Ehd'Ed Andrash
|
RU2199523C2 |
| THERAPEUTIC AGENT CONTAINING CARBOSTIRYL DERIVATIVE AND DONEPEZIL FOR TREATING ALZHEIMER'S DISEASE |
2008 |
|
RU2469723C2 |
| TRICYCLIC PYRAZOLE DERIVATIVES |
1995 |
|
RU2152388C1 |
| PYRROLE TRICYCLIC DERIVATIVES, A PHARMACEUTICAL PREPARATION |
1994 |
- Mikhaehl' Bes
- Jurgen Vikhmann
- Ul'Rikh Vidmer
|
RU2128649C1 |
| INTERMEDIATE PRODUCTS FOR PREPARATION OF 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANONE 2-YL)METHYLPIPERIDINE, METHOD OF PREPARATION THEREOF AND METHOD OF PREPARING 1- BENZYL-4-[(5,6-DIMETHOXY-1-INDANONE)-2-YL)METHYLPIPERIDINE AND USE THEREOF |
1996 |
|
RU2160731C2 |
| DERIVATIVES OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1999 |
- Brehnn Mark Robert
- Messier Terri
- Karrier Ehrika Ehnn
- Dadzhento Kataran Lauri
- Friberg Mikaehl'
- Sk'Erbek Nil'S
- Spehlding Trehjsi
|
RU2230740C2 |
| ARIPIPRAZOLE SALTS |
2006 |
- Pongo Laslo
- Shimig D'Jula
- Dancho Andrash
- Morov'Jan D'Erd'
|
RU2384572C2 |
| ARALKYLAMINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
1992 |
- Goto Giiti[Jp]
- Nagaoka Akinobu[Jp]
- Isikhara Judzi[Jp]
|
RU2021256C1 |
| NEW 1,4-DIAZA-BICYCLO[3,2,2]NONYL-OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL APPLICATION |
2007 |
- Peters Dan
- Ol'Sen Gunnar M.
- Nel'Sen Ehl'Sebet Ehstergord
- Timmermann Daniehl' B.
- Lokhel' Stiven Charl'Z
|
RU2427581C2 |
| DERIVATIVES OF PIPERAZINYLALKYLTHIOPYRIMIDINE, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND METHOD FOR PREPARING |
2000 |
- Ratsne Shimonek Ildiko
- Bozhing Daniehl'
- Nemet Gabor
- Shimig D'Jula
- Posavats Laslo
- Jakotsi Ivan
- Levai D'Erd'
- Gachal'I Ishtvan
- Tikhan'I Karoj
- Vellman Janosh
- Ehd'Ed Andrash
|
RU2245334C2 |
