4-(SULPHANILPYRIMIDINE-4-YLMETHYL)MORPHOLINE DERIVATIVES AS GABA-RECEPTOR LIGANDS FOR TREATING ANXIETY, DEPRESSION AND EPILEPSY Russian patent published in 2010 - IPC C07D239/38 C07D239/42 C07D403/06 C07D413/06 A61K31/506 A61K31/5377 A61P25/08 A61P25/22 A61P25/24 

FIELD: medicine.

SUBSTANCE: invention refers to compound of formula I wherein X represents -S- or -NH-; R¹ represents C_1-12alkyl, C_2-12alkenyl, phenyl C_1-12alkel, phenyl C_2-12alkenyl or phenyl-O-C_1-12alkyl and wherein said phenyl groups are optionally substituted with one or two assistants chosen from the group consisting of lower C_1-7alkyl, C C_1-7alkoxy and halogen C_1-7alkyl; R² represents hydrogen, lower C_1-7alkyl or C_3-6cycloalkyl; R³/R⁴ together with N-atom whereto attached, form nonaromatic 5,6-members heterocyclic ring system which optionally contains in addition to N-atom one additional heteroatom chosen from the group, consisting of O or N and where the ring system is optionally substituted group lower C_1-7alkyl, lower C_1-7alkoxy, -NR₂, -CONR₂; or R³/R⁴ together with N-atom whereto attached, can form heterocyclic ring system which contains at least two rings and which optionally contains one or two additional heteroatoms chosen from group, consisting of N and O; R represents hydrogen or lower C_1-7alkyl; R⁵ represents hydrogen or lower C_1-7alkyl; or to pharmaceutically acceptable additive salts with acid of this compound. The invention also concerns a medical product.

EFFECT: improved clinical effectiveness.

16 cl, 4 dwg, 3 tbl, 43 ex